منابع مشابه
miR-181 suppresses metastasis via MMP-14
deaths. Much effort has been made to identify key molecules controlling metastasis. However, due to the complicated wiring of the cancer signaling networks, key players initiating cancer metastasis have not been defined. This situation has thwarted target-based drug discovery aimed at preventing cancer metastasis. Regardless of which molecules initiate tumor, cancer cells must be equipped with ...
متن کاملmiR‑133a suppresses cell proliferation, migration and invasion in human lung cancer by targeting MMP‑14.
Lung cancer is the leading cause of cancer‑related mortality worldwide. Over half of lung cancer cases are diagnosed after metastasis, for which the median survival time is approximately 8 months. microRNAs (miRNAs), which are a class of single‑stranded endogenous non‑coding RNAs, are likely to be involved in most biological processes. miR‑133 plays roles in cardiac development and disease, and...
متن کاملMiR-519d-3p Suppresses Invasion and Migration of Trophoblast Cells via Targeting MMP-2
Our study was approved by the Medical Ethics Committee of Tang Du Hospital, Fourth Military Medical University and complied strictly with national ethical guidelines. Preeclampsia (PE) is a specific clinical disorder characterized by gestational hypertension and proteinuria and is a leading cause of maternal and perinatal mortality worldwide. The miR-519d-3p is upregulated in the maternal plasm...
متن کاملMiR-519d suppresses breast cancer tumorigenesis and metastasis via targeting MMP3
Breast cancer (BC) is the most common cause of death in women throughout the world. Although microRNAs (miRNAs) have been identified as novel regulators in carcinogenesis, there are still abundant hidden treasure needed to be excavated. In the present study, we found that miR-519d expression was remarkably decreased in both human BC tissues and MCF-7 cells. CCK8 and 5-Ethynyl-2'-deoxyuridine (E...
متن کاملCDK3, target of miR-4469, suppresses breast cancer metastasis via inhibiting Wnt/β-catenin pathway
Cyclin-dependent kinase 3 (CDK3), a member of CDK family, is involved in G0/G1 and G1/S cell cycle transitions. Although several researchers discovered that CDK3 related to cell growth in some kinds of cancer, the functions of CDK3 during tumor development remains unclear. Here, we first found that the expression of CDK3 was higher in primary tumors of non-metastatic breast cancer compared with...
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ژورنال
عنوان ژورنال: Aging
سال: 2015
ISSN: 1945-4589
DOI: 10.18632/aging.100824